Bullous lesions

Bullous lesions are a cutaneous manifestation of congenital syphilis and most often involve the hands and/or feet, but less often they can be more generalized. The bullous lesions, which are referred to as syphilitic pemphigus (or pemphigus syphiliticus), are characterized by large fluid-filled blisters that are fragile and typically rapidly evolve with desquamation and erosions. This manifestation, when present, typically occurs in the first few weeks of life and may even be present at birth.