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Lesson 22. Penicillin Allergy

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References

  • Gonzalez-Estrada A, Radojicic C. Penicillin allergy: A practical guide for clinicians. Cleve Clin J Med. 2015;82:295-300.

Tables

Table 1.

Gell and Coombs Classification of Hypersensitivity Reactions
Type of Reactions Hypersensitivity Mediated by Time of Onset Examples
IgE-mediated Type I IgE antibodies Within 1 hour Anaphylaxis
Non-IgE-mediated Type II Cytotoxic Hours to days Hemolytic anemia
Non-IgE-mediated Type III Immune complex 7-21 days Serum sickness
Non-IgE-mediated Type IV Cell-mediated Days to weeks Maculopapular rash
Stevens-Johnson syndrome
Toxic epidermal necrolysis

IgE = immunoglobulin E
Source:
  • Gonzalez-Estrada A, Radojicic C. Penicillin allergy: A practical guide for clinicians. Cleve Clin J Med. 2015;82:295-300. [PubMed Abstract]

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