Lesson 24. Scabies Table of ContentsScabiesReferencesTables PDF ShareReferencesAnderson AL, Chaney E. Pubic lice (Pthirus pubis): history, biology and treatment vs. knowledge and beliefs of US college students. Int J Environ Res Public Health. 2009;6:592-600.[PubMed Abstract] - Anderson KL, Strowd LC. Epidemiology, Diagnosis, and Treatment of Scabies in a Dermatology Office. J Am Board Fam Med. 2017 1/2;30:78-84.[PubMed Abstract] - Belvisi V, Orsi GB, Del Borgo C, et al. Large Nosocomial Outbreak Associated with a Norwegian Scabies Index Case Undergoing TNF-α Inhibitor Treatment: Management and Control. Infect Control Hosp Epidemiol. 2015;36:1358-60.[PubMed Abstract] - Bernigaud C, Fang F, Fischer K, et al. Preclinical Study of Single-Dose Moxidectin, a New Oral Treatment for Scabies: Efficacy, Safety, and Pharmacokinetics Compared to Two-Dose Ivermectin in a Porcine Model. PLoS Negl Trop Dis. 2016;10:e0005030.[PubMed Abstract] - Burkhart CG, Burkhart CN. Oral ivermectin for Phthirus pubis. J Am Acad Dermatol. 2004;51:1037-8.[PubMed Abstract] - Campbell JJ, Paulson CP, Nashelsky J. Clinical Inquiry: What is the most effective treatment for scabies? J Fam Pract. 2017;66:E11-E12.[PubMed Abstract] - Chosidow O, Fuller LC. Scratching the itch: is scabies a truly neglected disease? Lancet Infect Dis. 2017;17:1220-1221.[PubMed Abstract] - Chosidow O. Clinical practices. Scabies. N Engl J Med. 2006;354:1718-27.[PubMed Abstract] - Cook AM, Romanelli F. Ivermectin for the treatment of resistant scabies. Ann Pharmacother. 2003;37:279-81.[PubMed Abstract] - Currie BJ, McCarthy JS. Permethrin and ivermectin for scabies. N Engl J Med. 2010;362:717-25.[PubMed Abstract] - Dhana A, Yen H, Okhovat JP, Cho E, Keum N, Khumalo NP. Ivermectin versus permethrin in the treatment of scabies: A systematic review and meta-analysis of randomized controlled trials. J Am Acad Dermatol. 2018;78:194-198.[PubMed Abstract] - Dohvoma VA, Ebana Mvogo SR, Atangana PJA, Nyasse P, Epee E, Ebana Mvogo C. Phthirus pubis Infestation of the Eyelids Presenting as Chronic Blepharoconjunctivitis in a 6-Year-Old Girl: A Case Report. Case Rep Ophthalmol. 2018;9:30-34.[PubMed Abstract] - Elosua-González M, García-Zamora E. Crusted Scabies. N Engl J Med. 2017;377:476.[PubMed Abstract] - Flinders DC, De Schweinitz P. Pediculosis and scabies. Am Fam Physician. 2004;69:341-8.[PubMed Abstract] - Fuentes-Suárez A, González-Márquez TN. "Acrobatic" Lice. N Engl J Med. 2017;377:e19.[PubMed Abstract] - Gunning K, Pippitt K, Kiraly B, Sayler M. Pediculosis and scabies: treatment update. Am Fam Physician. 2012;86:535-41.[PubMed Abstract] - Huffam SE, Currie BJ. Ivermectin for Sarcoptes scabiei hyperinfestation. Int J Infect Dis. 1998;2:152-4.[PubMed Abstract] - Johnstone P, Stong M. Scabies. Am Fam Physician. 2015;92:919-20.[PubMed Abstract] - Koch E, Clark JM, Cohen B, et al. Management of head louse infestations in the United States—a literature review. Pediatr Dermatol. 2016;33:466-72.[PubMed Abstract] - Leone PA. Scabies and pediculosis pubis: an update of treatment regimens and general review. Clin Infect Dis. 2007;44 Suppl 3:S153-9.[PubMed Abstract] - Marin-Cabanas I, Pascual JC. Image Gallery: Dermoscopy of phthiriasis pubis: a handy and useful tool. Br J Dermatol. 2016;175:e94.[PubMed Abstract] - Micali G, Lacarrubba F, Verzì AE, Chosidow O, Schwartz RA. Scabies: Advances in Noninvasive Diagnosis. PLoS Negl Trop Dis. 2016;10:e0004691.[PubMed Abstract] - Ortega-Loayza AG, McCall CO, Nunley JR. Crusted scabies and multiple dosages of ivermectin. J Drugs Dermatol. 2013;12:584-5.[PubMed Abstract] - Roberts LJ, Huffam SE, Walton SF, Currie BJ. Crusted scabies: clinical and immunological findings in seventy-eight patients and a review of the literature. J Infect. 2005;50:375-81.[PubMed Abstract] - Romani L, Whitfeld MJ, Koroivueta J, et al. Mass Drug Administration for Scabies Control in a Population with Endemic Disease. N Engl J Med. 2015;373:2305-13.[PubMed Abstract] - Salavastru CM, Chosidow O, Boffa MJ, Janier M, Tiplica GS. European guideline for the management of scabies. J Eur Acad Dermatol Venereol. 2017;31:1248-1253.[PubMed Abstract] - Salavastru CM, Chosidow O, Janier M, Tiplica GS. European guideline for the management of pediculosis pubis. J Eur Acad Dermatol Venereol. 2017;31:1425-1428.[PubMed Abstract] - Shimose L, Munoz-Price LS. Diagnosis, prevention, and treatment of scabies. Curr Infect Dis Rep. 2013;15:426-31.[PubMed Abstract] - Wendel K, Rompalo A. Scabies and pediculosis pubis: an update of treatment regimens and general review. Clin Infect Dis. 2002;35:S146-51.[PubMed Abstract] - Workowski KA, Bolan GA; Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. Ectoparasitic infections. MMWR Recomm Rep. 2015;64(No. RR-3):1-137.[2015 STD Treatment Guidelines] - TablesTable 1. 2021 STI Treatment Guidelines: Ectoparasitic InfectionsTreatment of ScabiesNote: lindane was previously recommended as an alternative treatment for scabies, but lindane has been discontinued in the United States due to risk of neurotoxicity. Recommended for Treatment of Scabies Permethrin 5% creamPermethrin 5% creamTradename:Acticin, Elimite, Nixapplied to all areas of the body from the neck down and washed off after 8–14 hours Recommended for Treatment of Scabies IvermectinIvermectinTradename:Stromectol200 μg/kg body weight orally, repeated in 14 days*Note: *Oral ivermectin has limited ovicidal activity; a second dose is required for eradication. Recommended for Treatment of Scabies Ivermectin 1% creamIvermectin 1% creamTradename:Soolantraapplied to all areas of the body from the neck down and washed off after 8–14 hours^Note: ^Repeat treatment in 1 week if symptoms persistSource: Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. Ectoparasitic infections. MMWR Recomm Rep. 2021;70(No. RR-4):1-187. [2021 STI Treatment Guidelines]Table 2. 2015 STD Treatment Guidelines: Ectoparasitic InfectionsTreatment of Crusted ScabiesSubstantial treatment failure might occur with a single-dose topical scabicide or with oral ivermectin treatment. Combination treatment is recommended. Recommended for Treatment of Crusted Scabies Permethrin 5% creamPermethrin 5% creamTradename:Acticin, Elimite, Nixtopical, full-body application to be repeated daily for 7 days then 2 times per week until cureIvermectinIvermectinTradename:Stromectol200 ug/kg body weight on days 1, 2, 8, 9, and 15+Note: Additional ivermectin treatment on days 22 and 29 might be required for severe cases Recommended for Treatment of Crusted Scabies Tradename:full-body application to be repeated daily for 7 days then 2x weekly until discharge or cureIvermectinIvermectinTradename:Stromectol200 ug/kg body weight on days 1, 2, 8, 9, and 15+Note: Additional ivermectin treatment on days 22 and 29 might be required for severe casesLindane should be avoided because of the risks for neurotoxicity with heavy applications or denuded skin Share by e-mail From:Enter your e-mail address To: Enter the e-mail address of the recipient Your Message: Check-On-LearningQuestionsThe Check-on-Learning Questions are short and topic related. 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