Lesson 19. Mycoplasma genitalium Table of ContentsMycoplasma genitaliumReferencesTables PDF ShareReferencesBjartling C, Osser S, Persson K. Mycoplasma genitalium in cervicitis and pelvic inflammatory disease among women at a gynecologic outpatient service. Am J Obstet Gynecol. 2012;206:476.e1-8.[PubMed Abstract] - Cohen CR, Mugo NR, Astete SG, et al. Detection of Mycoplasma genitalium in women with laparoscopically diagnosed acute salpingitis. Sex Transm Infect. 2005;81:463-6.[PubMed Abstract] - Couldwell DL, Tagg KA, Jeoffreys NJ, Gilbert GL. Failure of moxifloxacin treatment in Mycoplasma genitalium infections due to macrolide and fluoroquinolone resistance. Int J STD AIDS. 2013;24:822-8.[PubMed Abstract] - Daley GM, Russell DB, Tabrizi SN, McBride J. Mycoplasma genitalium: a review. Int J STD AIDS. 2014;25:475-87.[PubMed Abstract] - Dehon PM, Hagensee ME, Sutton KJ, Oddo HE, Nelson N, McGowin CL. Histological Evidence of Chronic Mycoplasma genitalium-Induced Cervicitis in HIV-Infected Women: A Retrospective Cohort Study. J Infect Dis. 2016;213:1828-35.[PubMed Abstract] - Dehon PM, McGowin CL. The immunopathogenesis of Mycoplasma genitalium infections in women: A Narrative Review. Sex Transm Dis. 2017;44:428-432.[PubMed Abstract] - Dize L, Barnes P Jr, Barnes M, et al. Performance of self-collected penile-meatal swabs compared to clinician-collected urethral swabs for the detection of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Mycoplasma genitalium by nucleic acid amplification assays. Diagn Microbiol Infect Dis. 2016;86:131-5.[PubMed Abstract] - Falk L, Fredlund H, Jensen JS. Signs and symptoms of urethritis and cervicitis among women with or without Mycoplasma genitalium or Chlamydia trachomatis infection. Sex Transm Infect. 2005;81:73-8.[PubMed Abstract] - Falk L, Jensen JS. Successful outcome of macrolide-resistant Mycoplasma genitalium urethritis after spectinomycin treatment: a case report. J Antimicrob Chemother. 2017;72:624-625.[PubMed Abstract] - Francis SC, Kent CK, Klausner JD, et al. Prevalence of rectal Trichomonas vaginalis and Mycoplasma genitalium in male patients at the San Francisco STD clinic, 2005-2006. Sex Transm Dis. 2008;35:797-800.[PubMed Abstract] - Gaydos CA. Mycoplasma genitalium: Accurate diagnosis Is necessary for adequate treatment. J Infect Dis. 2017;216:S406-S411.[PubMed Abstract] - Getman D, Jiang A, O'Donnell M, Cohen S. Mycoplasma genitalium Prevalence, Coinfection, and Macrolide Antibiotic Resistance Frequency in a Multicenter Clinical Study Cohort in the United States. J Clin Microbiol. 2016;54:2278-83.[PubMed Abstract] - Golden MR, Workowski KA, Bolan G. Developing a Public Health Response to Mycoplasma genitalium. J Infect Dis. 2017;216:S420-S426.[PubMed Abstract] - Gottesman T, Yossepowitch O, Samra Z, Rosenberg S, Dan M. Prevalence of Mycoplasma genitalium in men with urethritis and in high risk asymptomatic males in Tel Aviv: a prospective study. Int J STD AIDS. 2017;28:127-32.[PubMed Abstract] - Haggerty CL, Taylor BD. Mycoplasma genitalium: an emerging cause of pelvic inflammatory disease. Infect Dis Obstet Gynecol. 2011;2011:959816.[PubMed Abstract] - Haggerty CL, Totten PA, Astete SG, Ness RB. Mycoplasma genitalium among women with nongonococcal, nonchlamydial pelvic inflammatory disease. Infect Dis Obstet Gynecol. 2006;2006:30184.[PubMed Abstract] - Horner PJ, Martin DH. Mycoplasma genitalium Infection in Men. J Infect Dis. 2017;216:S396-S405.[PubMed Abstract] - Jensen JS, Cusini M, Gomberg M, Moi H. 2016 European guideline on Mycoplasma genitalium infections. J Eur Acad Dermatol Venereol. 2016;30:1650-6.[PubMed Abstract] - Jensen JS, Cusini M, Gomberg M, Moi H. Background review for the 2016 European guideline on Mycoplasma genitalium infections. J Eur Acad Dermatol Venereol. 2016;30:1686-93.[PubMed Abstract] - Jernberg E, Moghaddam A, Moi H. Azithromycin and moxifloxacin for microbiological cure of Mycoplasma genitalium infection: an open study. Int J STD AIDS. 2008;19:676-9.[PubMed Abstract] - Jurstrand M, Jensen JS, Magnuson A, Kamwendo F, Fredlund H. A serological study of the role of Mycoplasma genitalium in pelvic inflammatory disease and ectopic pregnancy. Sex Transm Infect. 2007;83:319-23.[PubMed Abstract] - Lau A, Bradshaw CS, Lewis D, et al. The efficacy of azithromycin for the treatment of genital Mycoplasma genitalium: a systematic review and meta-analysis. Clin Infect Dis. 2015;61:1389-99.[PubMed Abstract] - Lis R, Rowhani-Rahbar A, Manhart LE. Mycoplasma genitalium infection and female reproductive tract disease: a meta-analysis. Clin Infect Dis. 2015;61:418-26.[PubMed Abstract] - Manhart LE, Broad JM, Golden MR. Mycoplasma genitalium: should we treat and how? Clin Infect Dis. 2011;53 Suppl 3:S129-42.[PubMed Abstract] - Manhart LE, Critchlow CW, Holmes KK, et al. Mucopurulent cervicitis and Mycoplasma genitalium. J Infect Dis. 2003;187:650-7.[PubMed Abstract] - Manhart LE, Jensen JS, Bradshaw CS, Golden MR, Martin DH. Efficacy of antimicrobial therapy for Mycoplasma genitalium infections. Clin Infect Dis. 2015;61 Suppl 8:S802-17.[PubMed Abstract] - Manhart LE. Has the time come to systematically test for Mycoplasma genitalium? Sex Transm Dis. 2009;36:607-8.[PubMed Abstract] - McGowin CL, Totten PA. The Unique microbiology and molecular pathogenesis of Mycoplasma genitalium. J Infect Dis. 2017 Jul 15;216:S382-S388.[PubMed Abstract] - Moi H, Reinton N, Moghaddam A. Mycoplasma genitalium in women with lower genital tract inflammation. Sex Transm Infect. 2009;85:10-4.[PubMed Abstract] - Munson E, Bykowski H, Munson KL, et al. Clinical Laboratory Assessment of Mycoplasma genitalium Transcription-mediated amplification using primary female urogenital specimens. J Clin Microbiol. 2016;54:432-8.[PubMed Abstract] - Oakeshott P, Aghaizu A, Hay P, et al. Is Mycoplasma genitalium in women the "New Chlamydia?" A community-based prospective cohort study. Clin Infect Dis. 2010;51:1160-6.[PubMed Abstract] - Read TRH, Fairley CK, Murray GL, et al. Outcomes of resistance-guided sequential treatment of Mycoplasma genitalium infections: a prospective evaluation. Clin Infect Dis. 2019;68:554-60.[PubMed Abstract] - Seña AC, Lensing S, Rompalo A, et al. Chlamydia trachomatis, Mycoplasma genitalium, and Trichomonas vaginalis infections in men with nongonococcal urethritis: predictors and persistence after therapy. J Infect Dis. 2012;206:357-65.[PubMed Abstract] - Short VL, Totten PA, Ness RB, Astete SG, Kelsey SF, Haggerty CL. Clinical presentation of Mycoplasma genitalium infection versus Neisseria gonorrhoeae infection among women with pelvic inflammatory disease. Clin Infect Dis. 2009;48:41-7.[PubMed Abstract] - Simms I, Eastick K, Mallinson H, et al. Associations between Mycoplasma genitalium, Chlamydia trachomatis, and pelvic inflammatory disease. Sex Transm Infect. 2003;79:154-6.[PubMed Abstract] - Stamm WE, Running K, Hale J, Holmes KK. Etiologic role of Mycoplasma hominis and Ureaplasma urealyticum in women with the acute urethral syndrome. Sex Transm Dis. 1983;10:318-22.[PubMed Abstract] - Svenstrup HF, Fedder J, Kristoffersen SE, Trolle B, Birkelund S, Christiansen G. Mycoplasma genitalium, Chlamydia trachomatis, and tubal factor infertility--a prospective study. Fertil Steril. 2008;90:513-20.[PubMed Abstract] - Taylor-Robinson D, Jensen JS. Mycoplasma genitalium: from Chrysalis to multicolored butterfly. Clin Microbiol Rev. 2011;24:498-514.[PubMed Abstract] - U.S. Food and Drug Administration. FDA permits marketing of first test to aid in the diagnosis of a sexually-transmitted infection known as Mycoplasma genitalium. January 23, 2019[FDA News Release] - Unemo M, Salado-Rasmussen K, Hansen M, et al. Clinical and analytical evaluation of the new Aptima Mycoplasma genitalium assay, with data on M. genitalium prevalence and antimicrobial resistance in M. genitalium in Denmark, Norway and Sweden in 2016. Clin Microbiol Infect. 2018;24:533-9.[PubMed Abstract] - Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. Mycoplasma genitalium. MMWR Recomm Rep. 2021;70(No. RR-4):1-187.[2021 STI Treatment Guidelines] - TablesTable 1. 2021 STI Treatment Guidelines: Mycoplasma genitaliumRecommended Regimens if M. genitalium Resistance Testing is Available Recommended if macrolide sensitive: Doxycycline followed by AzithromycinDoxycycline followed by AzithromycinTradename:Doxycycline 100 mg orally 2 times/day for 7 days, followed by Azithromycin 1 g orally initial dose, followed by 500 mg orally once daily for 3 additional days (2.5 g total of Azithromycin) Recommended if macrolide resistant: Doxycycline followed by MoxifloxacinDoxycycline followed by MoxifloxacinTradename:Doxycycline 100 mg orally 2 times/day for 7 days, followed by Moxifloxacin 400 mg orally once daily for 7 daysSource: Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. Mycoplasma genitalium. MMWR Recomm Rep. 2021;70(No. RR-4):1-187. [2021 STI Treatment Guidelines]Table 2. 2021 STI Treatment Guidelines: Mycoplasma genitaliumRecommended Regimens if M. genitalium Resistance Testing is Not Available Recommended if M. genitalium is detected by an FDA-cleared NAAT: Doxycycline followed by MoxifloxacinDoxycycline followed by MoxifloxacinTradename:Doxycycline 100 mg orally 2 times/day for 7 days, followed by Moxifloxacin 400 mg orally once daily for 7 daysSource: Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. Mycoplasma genitalium. MMWR Recomm Rep. 2021;70(No. RR-4):1-187. [2021 STI Treatment Guidelines] Share by e-mail From:Enter your e-mail address To: Enter the e-mail address of the recipient Your Message: Check-On-LearningQuestionsThe Check-on-Learning Questions are short and topic related. They are meant to help you stay on track throughout each lesson and check your understanding of key concepts.You must be signed in to customize your interaction with these questions. Funded by Centers for Disease Control and Prevention (CDC) Created at Part of CME provided by CNE approved by Since you've received 80% or better on this quiz, you may claim continuing education credit. You seem to have a popup blocker enabled. If you want to skip this dialog please Always allow popup windows for the online course. Current Version: nstdc-monorepo-499912e8-2026-02-26-231421 Sign In Register for new account Email address Please provide a valid email address. Password Please provide your password. Forgot password? Cancel Sign In Become a New User Account Registration Benefits: Track your progress on the lessons Earn free CNE/CME/CE Earn Certificates of Completion Access to other free IDEA curricula Create a free account to get started Register
